Neural systems mediating the inhibition of cocaine-seeking behaviors
نویسندگان
چکیده
منابع مشابه
The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior.
The role of limbic-striato-pallidal circuitry in cocaine-induced reinstatement was evaluated. The transient inhibition of brain nuclei associated with motor systems [including the ventral tegmental area (VTA), dorsal prefrontal cortex (dPFC), core of the nucleus accumbens (NAcore), and ventral pallidum (VP)] prevented cocaine-induced reinstatement. However, only the VP proved to be necessary fo...
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Inhibitory optogenetics was used to examine the roles of the prelimbic cortex (PL), the nucleus accumbens core (NAcore) and the PL projections to the NAcore in the reinstatement of cocaine seeking. Rats were microinjected into the PL or NAcore with an adeno-associated virus containing halorhodopsin or archaerhodopsin. After 12 days of cocaine self-administration, followed by extinction training...
متن کاملRole for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior.
Hypocretin-1 and -2 (Hcrt-1 and Hcrt-2), also referred to as orexin-A and -B, are neuropeptides synthesized by a few thousand neurons in the lateral hypothalamus. Hypocretin-containing neurons project throughout the brain, with a prominent input to basal forebrain structures involved in motivation, reward, and stress. However, the role of hypocretins in addiction-related behaviors remains large...
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Drug addiction is a chronic brain disease characterized by a persistent risk of relapse, even after a long period of abstinence. A current hypothesis states that relapse results from lasting neuroadaptations that are induced in response to repeated drug administration. The adaptations require gene expression, some of which being under the control of stable epigenetic regulations. We have previo...
متن کاملA Brief Review of Dopaminergic Mechanisms of Reconsolidation of Cocaine-Seeking Behaviors
Reconsolidation is a process in which memory undergoes a transiently labile stage after its retrieval and needs to be consolidated again in order to be maintained. Disruption of reconsolidation of drug memories dampens previous memories and therefore may provide a useful way to treat drug abuse. Based on the importance of the dopamine D1 and D3 receptors in mediating the acquisition of cocaine-...
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ژورنال
عنوان ژورنال: Pharmacology Biochemistry and Behavior
سال: 2018
ISSN: 0091-3057
DOI: 10.1016/j.pbb.2017.07.006